Follow up information with these participants also showed that there was some level of maintenance, suggesting that CBD could be effective for helping people stopping smoking in the long-term, even after people stop using it. A similar 2018 review built on this, noted that many studies have shown the anti-stress and antidepressant activity of CBD oil in animal trials. An interesting medical review from 2014 showing results from a variety of studies suggests that CBD acts as an antidepressant and antianxiety compound. A similar 2016 study found that CBD could also be used to help with pain in arthritis patients due to a reduction of pro-inflammatory biomarkers.